Sten Eirik W Jacobsen

Sten Eirik W. Jacobsen, MD, PhD, is a Professor of Stem Cell Biology and Regenerative Medicine at the Karolinska Institutet and at the University of Oxford. His research is focused at understanding how normal blood cell formation from stem cells in the bone marrow is organized and regulated to ensure replenishment of millions of blood cells per second, and how normal stem cells upon acquisition of oncogenic mutations are transformed into malignant stem cells. The aim is to unravel the dynamics of stem and progenitor cells in unperturbed hematopoiesis, and to identify and therapeutically target key cellular and molecular events in the transformation from normal to malignant hematopoiesis. Through these research directions the goal is to identify novel therapeutic strategies towards regenerative hematopoiesis and targeting of leukemic stem cells.